Russian scientists have proposed a way to detect kidney cancer at an early stage
Professor-researcher at the Institute of living systems of the Baltic Federal University named Kant (Kaliningrad) Liudmila Matskova, together with colleagues from China have proposed a method of detecting kidney cancer at an early stage on the basis of molecular biology techniques that will improve the effectiveness of treatment of this disease, reported the press service of the BFU.
Kidney cancer in most cases are asymptomatic, and clinical manifestations occur mainly in the later stages, when the treatment is ineffective. The average life expectancy of these patients is limited to a period of five years. It is therefore important to find ways to "detect" the beginning of tumor growth as early as possible. Now scientists have found that in cells of kidney cancer compared to their healthy "brothers" are decidedly less protein 4 cadherin – molecules, whose function is to "consolidate" normal cells together.
"Cadherin 4 "sits" on the surface of cells, helping them to communicate with each other, and "follows" that the cells were not divided," – said Matskova, words which are contained in the message.
According to her, the current study was conducted using a large set of samples – the authors studied almost 900 tissue samples of kidney cancer. The result has been to show that the attenuation of expression (biological synthesis) cadherin 4 in renal tissue may signal the beginning of the conversion of normal cells into malignant. "Starting point" for the study was the analysis of a database of different cancer types (The Cancer Genome Atla), which contains information about the genome of more than 11,000 primary malignant tumors, Matskova added.
Synthesis of 4 cadherin in the cells and its appearance on the surface of cells strictly koordiniruyutsya with the cell cycle, she added. "But if the expression of cadherin 4 fades on a regular basis, as in kidney cancer, the cells begin to multiply uncontrollably," said Matskova.
The results of the study, the results of which are published in international scientific journal Medical Science Monitor, is expected to help as early as possible and more precisely to identify kidney cancer, including the different subtypes of tumors, which in turn will give the opportunity to pick up effective treatment, to significantly improve the quality and length of life after diagnosis.