Russian scientists are "astrobotnia" vascular prostheses
Specialists of the research Institute for complex issues of cardiovascular diseases (NII KPSS, Kemerovo) made a new practical step towards the creation of cardiovascular prostheses of small diameter, which, when implanted in a living organism would not present a risk of blood clots, scientists were able to show the relative efficiency they created a vascular prostheses on large laboratory animals, reported the press service of the Institute.
Synthetic vascular prostheses interact with the blood and the surrounding tissues and soon after implantation, are covered with blood clots, which poses a threat to the health and lives of patients. So you want to create such an artificial vascular prosthesis which minimally would contribute to blood clot formation.
Informed biocompatible biodegradable samples of vascular prostheses with a diameter of 1.5 mm, developed in KPSS has already demonstrated its effectiveness on the model of the small laboratory animals - year patency (nearestbeast thrombi) of prostheses implanted in the aorta of laboratory rats, 93%, the report says.
Testing of these prostheses was extended to sheep, which have similarities to human anatomy and physiology of the cardiovascular system, but are, as they say scientists, is a very aggressive animal model in terms of thrombosis. On model large laboratory animals it is possible to identify all the risks of insolvency of the future of medical devices, said the press service of the Institute.
Surgery for implantation of vascular prosthesis in the carotid artery KPSS scientists spent 35 sheep. "Eighteen months patency of the prostheses identified in 50% of cases, while existing in the market of synthetic vascular grafts implanted sheep were trombirovanny in the first days after implantation in 100% of cases," - said in a press release.
In the manufacture of dentures have been used a number of tissue-engineered approaches for the surface modification of prostheses that stimulate the early formation of the basic elements of healthy vascular tissue, said head of the laboratory of cell technologies KPSS, doctor of medical Sciences Larisa Antonova.
The received results allow to speak about perspectivity of the first results that show that to create an effective vascular graft of small diameter – it's real, said the press service of the Institute. However, there is a lot of work on elimination of shortcomings identified in the conducted experiments, since the main goal of scientists is to create unconditionally effective vascular graft of small diameter with a minimum tendency to thrombosis.
These works will go under the new project, supported in 2020, the Russian science Foundation. The new project will also bring together scientists of the two institutes of the Novosibirsk Akademgorodok (employees of Institute of chemical biology and fundamental medicine, Siberian branch of the Russian Academy of Sciences and the Institute of nuclear physics Budker behalf of the Siberian branch of the Russian Academy of Sciences), as well as representatives of the faculty of chemistry of Lomonosov Moscow state University.